DHT hormone. Molecular model of the structure of the male sex hormone DHT (dihydrotestosterone, or 5-alpha-dihydrotestosterone). Atoms are represented as rods and are colour-coded: carbon (blue), hydrogen (gold), and oxygen (red). DHT is the most potent of the naturally-occurring androgens, the class of hormones associated with the development of male reproductive organs and secondary sex characteristics. It is secreted in the testes, prostate gland, hair follicles and adrenal glands. A DHT deficiency may lead to a variety of syndromes including hermaphroditism. These may be reduced by hormone replacement therapy.