Tuberous sclerosis. Face of a boy with tuberous sclerosis (TS). This condition, also known as Bourneville disease, is a hereditary condition characterised by the formation of hamartomas (abnormal growths) on the skin and other organs. Tuberous sclerosis primarily causes tuber-like growths on the brain, which calcify and harden (becoming sclerotic) with age. This may cause retardation and seizures. TS shows itself on the skin, as here, in a facial rash called angiofibroma. This affects the nose and cheeks, developing first as small red dots and later as fibromas (centre left). There is no cure for TS, but its symptoms can be treated and managed.