Steroid cream instructions. Hands holding a leaflet giving instructions for the application of the corticosteroid cream Trimovate. Trimovate, which contains the active ingredient clobetasone butyrate, is applied to the skin to treat eczema and dermatitis. Using more than the stated dose of a steroid cream can cause thinning of the skin and allow the absorption of the steroid into the blood supply. Trimovate is produced by GlaxoSmithKline.