Retinal pigment epithelial detachment. Ophthalmoscope view of the retina in a case of pigment epithelial detachment (PED). This condition occurs when fluid beneath the retinal pigment epithelium (RPE) causes detachment (circular area at left). The macula of the retina (left) is the area affected by the PED. The optic disc of the retina is at right where the blood vessels are converging. PED is associated with age-related macular degeneration and central serous choroidopathy. It can resolve without treatment, but may require drugs and laser therapy to repair the damage. For fluorescent angiography views of this retina, see images C025/7690 and C025/7926.