Insulin-degrading enzyme and inhibitor. Computer illustration showing the structure of the active site of a human insulin-degrading enzyme (IDE) complexed with a molecule of the BDM44768 IDE inhibitor (red). Acute treatment of mice with BDM44768 to inhibit the action of IDE has been shown to increase insulin signalling and impair glucose tolerance. This confirms that IDE is involved in pathways that modulate short-term glucose levels.
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Creative#:
TOP16636671
Source:
達志影像
Authorization Type:
RM
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須由TPG 完整授權
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N/A
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No
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activesiteartworkbdm44768biochemicalbiochemistrybiologicalbiologyboundcomplexcomplexedcutoutcutoutscut-outcut-outscutoutcutoutsenzymeglucoselevelglucosetolerancehumanideillustrationinhibitinginhibitioninhibitorinsulindegradinginsulinsignallinginsulin-degradingenzymelevelsmetabolicmetabolismmodulationmolecularmodelmolecularstructuremoleculemoleculesstructuralwhitebackground
activeartworkbackgroundbdm44768biochemicalbiochemistrybiologicalbiologyboundcomplexcomplexedcutcutcut-outcut-outscutoutcutoutsdegradingenzymeenzymeglucoseglucosehumanideillustrationinhibitinginhibitioninhibitorinsulininsulininsulin-degradinglevellevelsmetabolicmetabolismmodelmodulationmolecularmolecularmoleculemoleculesoutoutssignallingsitestructuralstructuretolerancewhite
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