HIV: site of action of antiretrovirals anti-HIV. On the left, the HIV virus binds to the CD4 T cell CD4 receptor, which will allow the co-receptor CCR5 to melt and release the viral RNA into the cytoplasm. After reverse transcription, the proviral DNA is integrated into the cellular genome and will synthesize viral precursor proteins and viral mRNA to then assemble and form new infectious viruses, released to the right of the image.