Craniopharyngioma, light micrograph. Craniopharyngioma is a燱HO Grade 1 epithelial tumour爑sually seen in the爏ellar/suprasellar region. It arises most likely from the爎emnants of Rathke's pouch. Some cases may have their origin in爉isplaced odontogenic rests along pituitary stalk. Grossly, they are often爏olid and cystic with areas of calcification. Craniopharyngiomas are subdivided into two types based on morphologic features: 1) Adamantinomatous (90% of cases) seen mostly in children and 2) Papillary (10% of cases) seen mostly in adults. The image shows adamantinomatous type. Microscopically, they are composed of well-differentiated squamous epithelium arranged in sheets, nodules, and anastomosing trabeculae with peripheral palisading. Within the nodules, the squamous cells often show whorl-like formation.