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Human SARM1 complexed with inhibitor dHNN, molecular model. SARM1 (sterile alpha and TIR motif containing 1) is an enzyme that is the most evolutionarily conserved member of the Toll-Interleukin receptor (TIR) family. SARM1 regulates axonal degeneration through its NAD-metabolizing activity and is a drug target for neurodegenerative disorders. It is shown in green and violet, the inhibitor dHNN (dehydronitrosonisodipine) in orange.

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