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Illustration of Cas12a (CRISPR associated protein 12a) complexed with its target DNA (deoxyribonucleic acid, purple and green) and guide RNA (ribonucleic acid, green and red) molecules. CRISPR-Cas complexes are used in genome engineering to cut DNA. Cas12a cuts both strands of the target DNA, but at slightly different locations, resulting in staggered ends with an overhang of four to five bases.

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