Oestradiol spray. A patient administering oestradiol transdermal spray by applying directly onto their forearm. Oestradiol (E2) is a naturally occurring steroid hormone, which is used as a hormone replacement therapy (HRT) drug for treating oestrogen deficiency symptoms. It is therefore most frequently used as a medication for menopausal women to reduce symptoms such as hot flushes and headaches. It is also used in hormonal birth control for women, and in hormone therapy for transgender women. It is sold under the brand name Lenzetto, which is a transdermal spray for administering oestradiol. It is applied by placing the device such that the plastic cone is resting on the skin of the forearm or thigh, and the pump is then pressed down fully to spray and administer one dose.