Light micrograph showing the conidia (asexual spores) from a Histoplasma capsulatum fungus. Two types of conidia are visible; there are multiple smaller microconidia and one macroconidium (larger, centre). This fungus is mostly found in soil, especially where bat and bird droppings are present. The spores can causes the disease histoplasmosis when inhaled. In most cases, people are not affected when they inhale these spores, but in some cases develop a fever, cough, and fatigue which typically self-resolve. In rare cases, particularly when patients are immunosuppressed, severe histoplasmosis can develop, and potentially affect almost any part of the body. This can lead to respiratory or bone marrow failure which can be fatal. Antifungal medication is the typical treatment course when necessary.