Claudius was the first Roman emperor to be born outside of Italy, and he was ostracised and exempted from public office for much of his life due to slight deafness and being afflicted with a limp. It was his infirmity that would save him from the noble purges that occurred during the reigns of Tiberius and Caligula, as he was not seen as a serious threat.

Due to being the last surviving man of the Julio-Claudian family, Claudius was declared emperor by the Praetorian Guard after their assassination of Caligula. Despite his only previous experience being sharing a consulship with his nephew Caligula in 37 CE, he proved to be a capable administrator, as well as an ambitious builder across the Empire. The conquest of Britain began under his reign, and his seeming vulnerability meant that Claudius often had to shore up his position, usually through the deaths of rival senators and nobles.

He was succeeded after his death in 54 CE by his adopted son, Nero.