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Anti-CRISPR protein AcrII complexed with Nme1Cas9-sgRNA, molecular model. Many bacteria use CRISPR-Cas to defend themselves against infection by viruses called phages. Phages encode a wide variety of proteins that inhibit CRISPR-Cas defences, with the most prominent being anti-CRISPR (Acr) proteins. Shown are the anti-CRISPR protein AcrII (blue), the nuclease Nme1Cas9 (dark magenta) and the sgRNA (single guide ribonucleic acid, green).

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