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Superantigen binding to a T-cell receptor, illustration. A superantigen (SAg, pink) is being presented by an antigen-presenting cell (bottom) to a T-cell (top), a type of white blood cell. Superantigens are released by some viruses and bacteria and can generate a strong immune response by inducing huge releases of cytokines in humans. The superantigen binds to the major histocompatibility complex (MHC) class II molecules (blue) of an antigen-presenting cell. This is then presented to a T-cell via a T-cell receptor (TCR, green). This activates the T-cell (non-specific activation), which results in excessive cytokine release.

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no-one nobody illustration artwork cgi digitally-generated digitally generated biology biological black background superantigen human apc antigen presenting cell antigen-presenting cell t-cell t cell tcr t-cell receptor t cell receptor cytokine cytokines cytokine release immune immune system immune response immunology immunological immunity white blood cell wbc virus bacteria recognition viral bacterial sag presentation presenting present excess excessive strong mhc major histocompatibility complex mhc class ii class ii mhc ii non-specific non-specific activation non specific non specific activation activation activates illness disorder disease unhealthy attachment complex binding bind bound cells cellular antigen antigenic epitope antigen presentation 3d 3 dimensional three dimensional biochemistry biochemical molecular biology cell biology molecular model protein proteins proteomics receptor receptor recognition receptor attachment t lymphocyte lymphocyte leukocyte structure structural microbiology microbiological

3 3d activates activation activation activation antigen antigen antigen antigen-presenting antigenic apc artwork attachment attachment background bacteria bacterial bind binding biochemical biochemistry biological biology biology biology black blood bound cell cell cell cell cell cell cells cellular cgi class class complex complex cytokine cytokine cytokines digitally digitally-generated dimensional dimensional disease disorder epitope excess excessive generated histocompatibility human ii ii ii illness illustration immune immune immune immunity immunological immunology leukocyte lymphocyte lymphocyte major mhc mhc mhc microbiological microbiology model molecular molecular no-one nobody non non non-specific non-specific present presentation presentation presenting presenting protein proteins proteomics receptor receptor receptor receptor receptor recognition recognition release response sag specific specific strong structural structure superantigen system t t t t-cell t-cell tcr three unhealthy viral virus wbc white

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